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human lp-pla2 enzyme elisa kit  (HotGen Ltd)

 
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    HotGen Ltd human lp-pla2 enzyme elisa kit
    Characteristics of the studied patients with vulnerable and non-vulnerable plaque.
    Human Lp Pla2 Enzyme Elisa Kit, supplied by HotGen Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/human lp-pla2 enzyme elisa kit/product/HotGen Ltd
    Average 90 stars, based on 1 article reviews
    human lp-pla2 enzyme elisa kit - by Bioz Stars, 2026-02
    90/100 stars

    Images

    1) Product Images from "Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis"

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    Journal: Frontiers in Neurology

    doi: 10.3389/fneur.2020.574036

    Characteristics of the studied patients with vulnerable and non-vulnerable plaque.
    Figure Legend Snippet: Characteristics of the studied patients with vulnerable and non-vulnerable plaque.

    Techniques Used: Significance Assay

    Odds ratios for diagnosis of plaque vulnerability in different models.
    Figure Legend Snippet: Odds ratios for diagnosis of plaque vulnerability in different models.

    Techniques Used: Biomarker Discovery, Significance Assay

    Homogeneity determination of lipoprotein-associated phospholipase A2 (Lp-PLA2) across the age strata and interaction of Lp-PLA2 with age.
    Figure Legend Snippet: Homogeneity determination of lipoprotein-associated phospholipase A2 (Lp-PLA2) across the age strata and interaction of Lp-PLA2 with age.

    Techniques Used: Significance Assay

    Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged ≤ 60 years old.
    Figure Legend Snippet: Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged ≤ 60 years old.

    Techniques Used:

    Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged > 60 years old.
    Figure Legend Snippet: Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged > 60 years old.

    Techniques Used:



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    Image Search Results


    Of 33 participants met the excluded criteria and 87 participants were included in this study for further analyzing. 30 age and gender-matched non-CSVD healthy controls (HC) were enrolled from physical examnination center. The plasma level of Lp-PLA2 and SOD was compared between CSVD and HC groups. In addition, The cognitive function and white matter hyperintensity were evaluated and the variables were collected and analyzed among groups.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: Of 33 participants met the excluded criteria and 87 participants were included in this study for further analyzing. 30 age and gender-matched non-CSVD healthy controls (HC) were enrolled from physical examnination center. The plasma level of Lp-PLA2 and SOD was compared between CSVD and HC groups. In addition, The cognitive function and white matter hyperintensity were evaluated and the variables were collected and analyzed among groups.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques:

    Baseline Characteristic of Study CSVD Population.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: Baseline Characteristic of Study CSVD Population.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques: Comparison

    ( A ) Comparison was made using independent t-test between the CSVD patients and HC (healthy control). The level of Lp-PLA2 increased and SOD decreased in CSVD patients. ( B ) Comparisons were made using one-way covariance with adjusted for the confounders (sex, age, education, BMI, cholesterol, HDL-C, LDL-C, urea, Cr, UA, hypertension, diabetes, CHD, APOE genotype, and medication use) followed by a post hoc Bonferroni test. Cognitive impairment group (MCI and SCI) displayed significantly lower levels of Lp-PLA2 and SOD than the normal cognition (NC) group (see also ). ( C ) The plasma Lp-PLA2 was linear correlated with SOD (r=0.327, p <0.05). Abbreviations: APOE, apolipoprotein E; BMI, body mass index; CHD, coronary heart disease; Cr, creatinine; CSVD, cerebral small vessel disease; HC, healthy control; HDL-C, High-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp-PLA2, Lipoprotein-associated Phospholipase A2; MCI: mild cognitive impairment; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NC, normal cognition; SCI, severe cognitive impairment; SOD, Superoxide Dismutase; UA, uric acid. * Compared to NC p <0.05, ** Compared to NC p <0.01, *** Compared to NC p <0.001, ## Compared to MCI p <0.01.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: ( A ) Comparison was made using independent t-test between the CSVD patients and HC (healthy control). The level of Lp-PLA2 increased and SOD decreased in CSVD patients. ( B ) Comparisons were made using one-way covariance with adjusted for the confounders (sex, age, education, BMI, cholesterol, HDL-C, LDL-C, urea, Cr, UA, hypertension, diabetes, CHD, APOE genotype, and medication use) followed by a post hoc Bonferroni test. Cognitive impairment group (MCI and SCI) displayed significantly lower levels of Lp-PLA2 and SOD than the normal cognition (NC) group (see also ). ( C ) The plasma Lp-PLA2 was linear correlated with SOD (r=0.327, p <0.05). Abbreviations: APOE, apolipoprotein E; BMI, body mass index; CHD, coronary heart disease; Cr, creatinine; CSVD, cerebral small vessel disease; HC, healthy control; HDL-C, High-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp-PLA2, Lipoprotein-associated Phospholipase A2; MCI: mild cognitive impairment; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NC, normal cognition; SCI, severe cognitive impairment; SOD, Superoxide Dismutase; UA, uric acid. * Compared to NC p <0.05, ** Compared to NC p <0.01, *** Compared to NC p <0.001, ## Compared to MCI p <0.01.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques: Comparison

    ( A ) The representative MRI imagings of WMHs in CSVD patients with different severity classified by Fazekas Scores. The levels of Lp-PLA2 (B) and SOD (C) were relatively lower in the CSVD patients of Severe-W compared to those in the Mild-W. The scores of MMSE (D) and MoCA (E) were lower in patients in the Severe-W group compared to those in the Mild-W group. Abbreviations: CSVD, cerebral small vessel diseases; MMSE, Mini-Mental State Examination; Mild-W, Mild-White matter hyperintensities, MoCA, Montreal Cognitive Assessment; Modest-W, Modest- White matter hyperintensities, MRI, Magnetic Resonance Imaging; Severe-W, Severe-White matter hyperintensities, SOD, Superoxide Dismutase; WMHs, White matter hyperintensities. * Compared to Mild-W p <0.05, ** Compared to Mild-W p <0.01.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: ( A ) The representative MRI imagings of WMHs in CSVD patients with different severity classified by Fazekas Scores. The levels of Lp-PLA2 (B) and SOD (C) were relatively lower in the CSVD patients of Severe-W compared to those in the Mild-W. The scores of MMSE (D) and MoCA (E) were lower in patients in the Severe-W group compared to those in the Mild-W group. Abbreviations: CSVD, cerebral small vessel diseases; MMSE, Mini-Mental State Examination; Mild-W, Mild-White matter hyperintensities, MoCA, Montreal Cognitive Assessment; Modest-W, Modest- White matter hyperintensities, MRI, Magnetic Resonance Imaging; Severe-W, Severe-White matter hyperintensities, SOD, Superoxide Dismutase; WMHs, White matter hyperintensities. * Compared to Mild-W p <0.05, ** Compared to Mild-W p <0.01.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques: Magnetic Resonance Imaging

    ( A ) Lp-PLA2 level in plasma samples were measured. After adjusting for confounders, Lp-PLA2 linear correlated with cognitive impairment severity as measured by MMSE scores (r=0.438, p <0.001). ( B ) A similar trend was observed between SOD and MMSE score, and the correlation was statistically significant (r=0.379, p <0.01). ( C ) After adjusting for confounders, Lp-PLA2 linear correlated with cognitive impairment severity as measured by MoCA scores (r=0.397, p <0.001). ( D ) A similar trend was observed between SOD and MoCA score, and the correlation was statistically signficant (r=0.443, p <0.001). Abbreviations: Lp-PLA2, Lipoprotein-associated Phospholipase A2; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; SOD, Superoxide Dismutase.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: ( A ) Lp-PLA2 level in plasma samples were measured. After adjusting for confounders, Lp-PLA2 linear correlated with cognitive impairment severity as measured by MMSE scores (r=0.438, p <0.001). ( B ) A similar trend was observed between SOD and MMSE score, and the correlation was statistically significant (r=0.379, p <0.01). ( C ) After adjusting for confounders, Lp-PLA2 linear correlated with cognitive impairment severity as measured by MoCA scores (r=0.397, p <0.001). ( D ) A similar trend was observed between SOD and MoCA score, and the correlation was statistically signficant (r=0.443, p <0.001). Abbreviations: Lp-PLA2, Lipoprotein-associated Phospholipase A2; MMSE, Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; SOD, Superoxide Dismutase.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques:

    Ordinal logistic regression of possible variables associated with cognitive decline in CSVD.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: Ordinal logistic regression of possible variables associated with cognitive decline in CSVD.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques:

    ( A ) Lp-PLA2 and SOD for CSVD patients with MCI versus CSVD patients with NC. The combined graph showed the Lp-PLA2 (black curve), SOD (red curve) and the combination curve (green curve) respectively. The combination of Lp-PLA2 and SOD was the best discriminating parameters compared to Lp-PLA2 and SOD alone. ( B ) ROC analysis of Lp-PLA2 and SOD for CSVD patients with SCI versus NC. The AUC was 0.85 for Lp-PLA2 (black curve), 0.84 for SOD (red curve) and 0.90 for the combination of Lp-PLA2 and SOD (green curve). Abbreviations: CSVD, Lp-PLA2, Lipoprotein-associated Phospholipase A2; SOD, Superoxide Dismutase; MCI, Mild Cognitive Impairment; SCI, severe cognitive impairment.

    Journal: Aging and Disease

    Article Title: Plasma Lipoprotein-associated Phospholipase A2 and Superoxide Dismutase are Independent Predicators of Cognitive Impairment in Cerebral Small Vessel Disease Patients: Diagnosis and Assessment

    doi: 10.14336/AD.2019.0304

    Figure Lengend Snippet: ( A ) Lp-PLA2 and SOD for CSVD patients with MCI versus CSVD patients with NC. The combined graph showed the Lp-PLA2 (black curve), SOD (red curve) and the combination curve (green curve) respectively. The combination of Lp-PLA2 and SOD was the best discriminating parameters compared to Lp-PLA2 and SOD alone. ( B ) ROC analysis of Lp-PLA2 and SOD for CSVD patients with SCI versus NC. The AUC was 0.85 for Lp-PLA2 (black curve), 0.84 for SOD (red curve) and 0.90 for the combination of Lp-PLA2 and SOD (green curve). Abbreviations: CSVD, Lp-PLA2, Lipoprotein-associated Phospholipase A2; SOD, Superoxide Dismutase; MCI, Mild Cognitive Impairment; SCI, severe cognitive impairment.

    Article Snippet: Lp-PLA2 mass was detected with the Human PLA2G7/PAF-AH/Lp-PLA2 Quantikine Enzyme-linked Immunosorbent Assay (ELISA) Kit (Bio-Techne Corporation, R&D system, Minnesota) according to the referenced instructions by Packard et al. and the manufacturer’s instructions [ ].

    Techniques:

    Characteristics of the studied patients with vulnerable and non-vulnerable plaque.

    Journal: Frontiers in Neurology

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    doi: 10.3389/fneur.2020.574036

    Figure Lengend Snippet: Characteristics of the studied patients with vulnerable and non-vulnerable plaque.

    Article Snippet: Samples for measurement of Lp-PLA2 mass were handled simultaneously by a professional technician using the human Lp-PLA2 enzyme ELISA kit (Hotgen, Beijing, China).

    Techniques: Significance Assay

    Odds ratios for diagnosis of plaque vulnerability in different models.

    Journal: Frontiers in Neurology

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    doi: 10.3389/fneur.2020.574036

    Figure Lengend Snippet: Odds ratios for diagnosis of plaque vulnerability in different models.

    Article Snippet: Samples for measurement of Lp-PLA2 mass were handled simultaneously by a professional technician using the human Lp-PLA2 enzyme ELISA kit (Hotgen, Beijing, China).

    Techniques: Biomarker Discovery, Significance Assay

    Homogeneity determination of lipoprotein-associated phospholipase A2 (Lp-PLA2) across the age strata and interaction of Lp-PLA2 with age.

    Journal: Frontiers in Neurology

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    doi: 10.3389/fneur.2020.574036

    Figure Lengend Snippet: Homogeneity determination of lipoprotein-associated phospholipase A2 (Lp-PLA2) across the age strata and interaction of Lp-PLA2 with age.

    Article Snippet: Samples for measurement of Lp-PLA2 mass were handled simultaneously by a professional technician using the human Lp-PLA2 enzyme ELISA kit (Hotgen, Beijing, China).

    Techniques: Significance Assay

    Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged ≤ 60 years old.

    Journal: Frontiers in Neurology

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    doi: 10.3389/fneur.2020.574036

    Figure Lengend Snippet: Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged ≤ 60 years old.

    Article Snippet: Samples for measurement of Lp-PLA2 mass were handled simultaneously by a professional technician using the human Lp-PLA2 enzyme ELISA kit (Hotgen, Beijing, China).

    Techniques:

    Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged > 60 years old.

    Journal: Frontiers in Neurology

    Article Title: Association Between Plasma Lipoprotein-Associated Phospholipase A2 and Plaque Vulnerability in TIA Patients With Unilateral Middle Cerebral Artery Stenosis

    doi: 10.3389/fneur.2020.574036

    Figure Lengend Snippet: Multivariate logistic regression analysis of variables associated with plaque vulnerability in studied patients aged > 60 years old.

    Article Snippet: Samples for measurement of Lp-PLA2 mass were handled simultaneously by a professional technician using the human Lp-PLA2 enzyme ELISA kit (Hotgen, Beijing, China).

    Techniques: